Disadvantages of using biological variation data for reference change values.

Volume 1 • Issue 4 • 1000e104 Biochem Anal Biochem ISSN:2161-1009 Biochem, an open access journal Biological Variation (BV) of quantities examined in laboratory medicine can be described as of three types, namely; variation over the span of life, predictable cyclical variation that can be daily, monthly or seasonal in nature, and random variation [1]. Random variations of analytes which consist of random fluctuation around the setting point of each individual is known as the intra-individual biological variation. Additionally, each person’s setting point may be different from another’s, and the overall variation resulting from this difference is known as inter-individual biological variation. In mathematical terms, these are usually expressed as Coefficients Of Variation (CV) and termed as CVw for intra-individual BV and CVg for inter-individual BV [2].